Tesamorelin is a synthetic analogue of growth hormone–releasing hormone (GHRH), developed to stimulate the natural production and release of growth hormone from the pituitary gland. It is a 44–amino acid peptide, structurally modified to improve stability and extend activity compared to native GHRH. Tesamorelin has been studied extensively for its ability to reduce visceral adipose tissue, particularly in patients with HIV-associated lipodystrophy, and has demonstrated promising results in promoting fat loss while preserving lean body mass. Beyond metabolic effects, research has also explored tesamorelin’s role in neuroprotection, cognitive support, and potential applications in age-related decline.
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