MOTS-c is a unique peptide encoded not by our nuclear DNA, but by the mitochondria—our cellular powerhouses. It functions as a crucial metabolic regulator, and its levels naturally decline with age. Often called an “exercise-mimetic,” MOTS-c activates key metabolic pathways, like AMPK, to improve insulin sensitivity and boost energy utilization, similar to the effects of physical activity.
Preclinical studies are highly promising, showing it can enhance physical performance, combat obesity, and protect against heart disease in animal models. While human trials are in early stages, a MOTS-c analog has shown good safety and positive results for liver disease in a clinical trial. This research highlights MOTS-c as a potential next-generation therapeutic for tackling age-related chronic diseases. It is currently available for research purposes only and is not an approved medical treatment.
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